Many people use evening primrose oil for treatment of scaly itchy rashes (atopic dermatitis), rheumatoid arthritis, and for relief of menopausal and premenstrual symptoms.
A Cochrane review published in 2012 showed that dietary supplements such as Vitamin D, primrose oil, hempseed oil, and sea buckthorn oil had no benefits in patient with eczema.
Studies that looked at using primrose oil for menopausal and premenstrual symptoms appear to show negligible results similar to participants who had been given a placebo.
A 2011 Cochrane review suggested that there was moderate evidence to support the use of oils containing gamma linoleic acid (in evening primrose, borage, or blackcurrant seed oil) in relieving symptoms of rheumatoid arthritis. However, the review also mentioned that further investigations into how effective these oils are and their side effects are warranted.
My 2 cents? Health Canada's review of evening primrose oil states that it is safe to consume 1300-1600mg/ day "for maintenance of good health." If your dose falls within these safe guidelines and you feel a benefit from its use, I'd suggest that it's likely safe to continue using it unless otherwise recommended by your health care providers.
Information Sources
http://www.ncbi.nlm.nih.gov/pubmed/22336810
http://www.ncbi.nlm.nih.gov/pubmed/22139538
http://www.ncbi.nlm.nih.gov/pubmed/21328257
Evening Primrose Oil Health Canada Monograph
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